The University’s Institute of Translational Medicine has been awarded £1.8m funding from the UK National Institute of Health Research (NIHR) to run a large study into the drug treatment of bleeding after childbirth (also called postpartum haemorrhage or PPH).
PPH is often defined as the loss of more than 500ml or 1,000ml of blood within the first 24 hours following childbirth. It is a common maternity emergency affecting 40,000 British women each year. Although it can usually be treated in the UK, it can lead to long-lasting complications.
Globally, however, it remains a major cause of death and is responsible for around 25% of the 289,000 maternal deaths annually. It is estimated that somewhere in the world a woman dies from PPH every 6 minutes.
Most effective treatment?
Currently PPH is commonly treated injections of either oxytocin or carboprost.
Oxytocin is a natural hormone-like substance that causes the uterus to contract. Oxytocin is used to induce labour or strengthen labour contractions during childbirth, and to control bleeding after childbirth.
Carboprost is a form of prostaglandin (a hormone-like substance that occurs naturally in the body). Prostaglandins help to control functions in the body such as blood pressure and muscle contractions.
At this time it is not known which is more effective in the treatment of PPH.
The study, entitled the ‘Carboprost or Oxytocin Postpartum haemorrhage Effectiveness’ (COPE) study, will compare the use of these injections and will involve nearly 4,000 women with PPH from 40 hospitals around the UK.
Women taking part will receive one of the two injections, along with a matching dummy drug. In this way, no-one will know which drug they have received. It is only when the study is over and the codes are broken that the outcomes can be compared between the half who received oxytocin and the half who received carboprost.
Professor Andrew Weeks, Consultant Obstetrician at Liverpool Women’s Hospital and Chief Investigator for the study, said: “We are delighted to be part of this important study that has the chance to improve the care of so many women.
“Bleeding after childbirth can happen very quickly and it is important that we get the treatment right. This will allow women to get on with the important matter of caring for their new baby, rather than having to spend their time recovering.”
For more information about Professor Weeks’ research can be found here.
You must be logged in to post a comment.
All recent news
Study Abroad Fair 2019: Where will your degree take you?
Study finds darker ants dominate the rainforest canopy
Professor Tom Solomon elected to RCP Council
5 ways reading can help your wellbeing
Celebrating 100 years of oceanography
At midnight tonight abortion will be decriminalised in Northern Ireland. It’s been a long time coming but #TheNorthIsNow Next up- #Gibraltar The fight for reproductive rights continues until #freesafelegallocal is also #universal Reproductive rights are human rights
EPISODE TWO out now features leaders in education... Dame Janet Beer @LivUni and Leonor Stjepic @MontessoriUK discussing what it means today to be work-ready, thinking on your feet and finding female role models. Please take a listen https://t.co/p9AKCRQ5dY
"Boris Johnson’s form of #Brexit is perhaps the biggest ever shift to a united Ireland..." writes Prof @JonTonge for the Belfast Telegraph > https://t.co/b9PF7c2Ep0