Sign in: Staff/Students
University researchers, working with F2G Limited (Eccles, Manchester), have developed a new antifungal drug to help in the treatment of life threatening invasive fungal infections such as invasive aspergillosis.
Invasive fungal infections are common and often lethal. Despite optimal medical care mortality is 20-30% at six weeks and dramatically rises to 80-100% for drug resistant infection.
These infections occur most commonly in the context of leukemia and bone marrow transplantation and often in young patients with otherwise curable disease.
The researchers, led by Professor William Hope from the University’s Antimicrobial Pharmacodynamics and Therapeutics (APT) Group, have characterised the biochemical and physiologic effects (pharmacodynamics) of F901318, which is the lead compound of the new class of drugs termed the ‘orotomides’.
The ‘orotomides’, discovered by F2G Limited, have a novel mechanism of action which is the specific biochemical interaction through which a drug substance produces its pharmacological effect.
This is the first new class of antifungal agent to be discovered in the last three decades.
The study, which was supported by a research grant by F2G, has been published in mBio.
APT’s work provides the underpinning evidence for efficacy and dosage justification for the very first patients receiving the new drug. Such information is required by regulatory agencies such as the European Medicines Agency and the Food and Drug Administration before clinical studies can proceed.
Professor Hope, said: “Antifungal resistance represents a major global clinical challenge. This study provides the necessary information to enable F901318 to be developed for clinical use.”
The full paper, ‘Pharmacodynamics of the Orotomides against Aspergillus fumigatus: New Opportunities for Treatment of Multidrug-Resistant Fungal Disease’, can be found here.
More information about Professor Hope’s research can be found here.
You must be logged in to post a comment.
All recent news
Winter break: How to travel safety
Liverpool academics named in global list of influential researchers
Liverpool invests in immunology cancer research
Insider Imprint student journal launches new podcast series
Event today: Brexit Information for EU Students
1/ Today, we are launching the latest COVID-19 Policy Brief with @LpoolCityRegion, a paper by Prof Simeon Yates, Associate PVC @LivUni, "COVID-19 & Digital Exclusion: Insights & Implications for the Liverpool City Region" https://bit.ly/2UGIfIZ
WE’RE LIVE! 💰
Join @KieranMaguire and @introspective81 for a tell-all talk on finance in the modern game.
If you’re after no-nonsense takes on Project Big Picture, European breakaways and club ownership, this one’s definitely for you.
STREAMING NOW: https://youtu.be/DwAf9e2_bew
World-leading experimental cancer researcher Professor Christian Ottensmeier has joined Liverpool to lead a major new programme of cutting-edge #immunology #cancer research in collaboration with local #NHS partners.
Full story ➡️ https://bit.ly/2V1tpga