A major lung cancer screening trial, conducted by experts at the University of Liverpool, has found that patients with a high risk of developing lung cancer can be identified with early stage disease and have up to a 73% chance of surviving five years or more.
The UK Lung Cancer Screening Trial (UKLS) was undertaken in partnership with Liverpool Heart & Chest Hospital, Papworth Hospital and the Royal Brompton & Harefield Hospital with the aim of highlighting the need for a screening programme to help benefit people who are at risk of developing lung cancer.
The Chief Investigator of the UKLS trial is Professor John Field, who is based in the University’s Institute of Translational Medicine.
Identifying those at risk
Lung cancer kills more people than any other cancer. The number of deaths in 2012 in the UK was 35,370, making lung cancer the commonest cause of cancer death in the UK for both men and women.
The main reasons why lung cancer outcomes are so poor, are that approximately 70% of patients first present to specialist care with incurable advanced disease and current treatment at this late stage has very little effect on mortality.
However, if a patient’s lung cancer is identified at an early stage, then the clinical outcome is greatly improved. Individuals with very early stage disease have up to a 73% chance of surviving for five years or more and over 80% have had surgical interventions. As a result there is a major national and international focus on CT screening trials.
National screening programme
The results of the UKLS trial provide further evidence for the UK National Screening Committee (UKNSC) to consider when making a decision whether to implement a national screening programme in the UK in the future.
Funded by the NIHR Health Technology Assessment programme the trial was the first and only lung cancer screening trial to take place in the UK and has provided in depth information on how to set up a national lung cancer CT screening programme, including using a risk prediction model to identify high risk individuals in the population.
State-of-the-art approach
UKLS is a randomised controlled trial of lung cancer screening versus usual care in 4055 individuals that used a population-based questionnaire to identify high-risk individuals. The screening, used a low dose of an imaging procedure that uses special x-ray equipment to create detailed pictures, or scans, of areas inside the body called Low Dose Computed tomography (LDCT).
In the USA’s National Lung Cancer Screening Trial, LDCT was shown to reduce lung cancer mortality by 20%. The UKLS screening trial also used a ‘state of the art approach’ to identify very early lung cancer nodules.
The UKLS trial has received full ethical approval and has been funded by the NIHR Health Technology Assessment programme and the results have been published in full in the HTA Publications today.
Health economic analysis also suggests that the screening intervention could be cost effective—this needs to be confirmed using data on observed lung cancer mortality reduction
Improving survival rates
Professor John Field, Clinical Professor of Molecular Oncology and the Chief Investigator of the UKLS trial, said: “The UKLS trial has successfully demonstrated that we have a way to screen for lung cancer in high risk individuals in the UK.
“However, as UKLS was a pilot trial, researchers are currently awaiting the outcome of the Dutch CT screening trial, which will potentially provide mortality data to argue for implementation of a national lung cancer screening programme in the UK.
“If we could detect lung cancer via screening of high risk individuals, it would make a major impact on the diagnosis of lung cancer at an earlier stage of the disease and would greatly improve the survival rates of those affected by this terrible disease.”
A copy of the full report can be found here.
