Pomegranate seed is particularly rich in the steroid beta-sitosterol
Scientists at the University of Liverpool and the Suranaree University of Technology, Thailand, have found that a naturally occurring steroid, present in pomegranate seed, could be used to stimulate uterine contractions.
The team identified beta-sitosterol – a steroid that can inhibit the absorption of cholesterol in the intestine – as the main constituent of pomegranate seed extract. The research suggests that pomegranate extract could be used as a natural stimulant to encourage the uterus to contract during labour.
Pomegranate juice is thought to have a number of health benefits, from lowering cholesterol and blood pressure to protecting against some cancers, but until now there has been no evidence to demonstrate its effects on the uterus. Researchers investigated pomegranate seed extract – more highly concentrated than pomegranate juice – and its effect on uterine smooth muscle samples.
Professor Sue Wray, from the University’s Department of Physiology, said: “Previous study has suggested that the pomegranate’s antioxidant and anti-inflammatory properties have a positive impact on health. We wanted to understand its effect on uterine contractions to help us explore new ways of treating women who may experience difficult labours. Currently the only available drug to treat women with a poorly contracting uterus is oxytocin, a hormone which only works approximately 50% of the time.
“It is important for us to investigate how the uterus works and what happens when it does not contract normally so that women experiencing problems during labour do not have to undergo major surgery to deliver a healthy baby.”
Dr Sajeera Kupittayanant, from Suranaree’s Institute of Science, explains: “We found that beta-sitosterol was the main constituent of pomegranate extract, a steroid present in many plant species, but particularly rich in pomegranate seed. We added the extract to uterus tissue samples from animals and found that the muscle cells increased their activity. Our work suggests that the increase is due to a rise in calcium, which is necessary in order for any muscle to contract, but is usually affected by hormones, nerve impulses and some drug treatments.
“The next step is to investigate how beta-sitosterol in pomegranate extract could increase calcium, but it could prove to be a significant step forward in identifying new ways of treating dysfunctional labour.”
The research, published in Reproductive Sciences, will support work being conducted at a new centre dedicated to improving experiences in pregnancy and childbirth for women across the world. The Centre for Better Births will bring together researchers and clinicians to improve understanding in areas such as premature labour, recurrent miscarriage and prolonged labour.
1. Advice to patients:
Researchers used pomegranate seed extract, which is more highly concentrated than pomegranate juice. More research is needed to understand if eating the fruit or drinking its juice has any impact on uterine contractions.
2. The University of Liverpool is a member of the Russell Group of leading research-intensive institutions in the UK. It attracts collaborative and contract research commissions from a wide range of national and international organisations valued at more than £93 million annually.
You must be logged in to post a comment.
All recent news
£460k boost for clinical trials methodology research partnership
Explore The Viking Age in the North West with new app
Top 10 tips to manage exam stress
Alumnus receives top honour from Institute of Electrical and Electronics Engineers (IEEE)
Being a dog lover is in your genes, study finds
Should the UK voting age be lowered? Our VC Professor Dame Janet Beer introduces @LivUniPol Prof Jon Tonge at tonight's #LivOpenHouse event, '16 - old enough to have sex but not to vote?'
Explore Viking #Wirral with our new, free The #Viking Age in the North West app! Available for #Android and #iOS. All the details > https://t.co/mhd6yvMPit
On the 50th anniversary of the UK becoming the first state to lower the voting age to 18, tonight's #LivOpenHouse event (6pm) looks at arguments for and against further lowering to 16, as has happened in Scotland for most elections and is happening in Wales. Good or bad idea?