Sign in: Staff/Students
Pomegranate seed is particularly rich in the steroid beta-sitosterol
Scientists at the University of Liverpool and the Suranaree University of Technology, Thailand, have found that a naturally occurring steroid, present in pomegranate seed, could be used to stimulate uterine contractions.
The team identified beta-sitosterol – a steroid that can inhibit the absorption of cholesterol in the intestine – as the main constituent of pomegranate seed extract. The research suggests that pomegranate extract could be used as a natural stimulant to encourage the uterus to contract during labour.
Pomegranate juice is thought to have a number of health benefits, from lowering cholesterol and blood pressure to protecting against some cancers, but until now there has been no evidence to demonstrate its effects on the uterus. Researchers investigated pomegranate seed extract – more highly concentrated than pomegranate juice – and its effect on uterine smooth muscle samples.
Professor Sue Wray, from the University’s Department of Physiology, said: “Previous study has suggested that the pomegranate’s antioxidant and anti-inflammatory properties have a positive impact on health. We wanted to understand its effect on uterine contractions to help us explore new ways of treating women who may experience difficult labours. Currently the only available drug to treat women with a poorly contracting uterus is oxytocin, a hormone which only works approximately 50% of the time.
“It is important for us to investigate how the uterus works and what happens when it does not contract normally so that women experiencing problems during labour do not have to undergo major surgery to deliver a healthy baby.”
Dr Sajeera Kupittayanant, from Suranaree’s Institute of Science, explains: “We found that beta-sitosterol was the main constituent of pomegranate extract, a steroid present in many plant species, but particularly rich in pomegranate seed. We added the extract to uterus tissue samples from animals and found that the muscle cells increased their activity. Our work suggests that the increase is due to a rise in calcium, which is necessary in order for any muscle to contract, but is usually affected by hormones, nerve impulses and some drug treatments.
“The next step is to investigate how beta-sitosterol in pomegranate extract could increase calcium, but it could prove to be a significant step forward in identifying new ways of treating dysfunctional labour.”
The research, published in Reproductive Sciences, will support work being conducted at a new centre dedicated to improving experiences in pregnancy and childbirth for women across the world. The Centre for Better Births will bring together researchers and clinicians to improve understanding in areas such as premature labour, recurrent miscarriage and prolonged labour.
1. Advice to patients:
Researchers used pomegranate seed extract, which is more highly concentrated than pomegranate juice. More research is needed to understand if eating the fruit or drinking its juice has any impact on uterine contractions.
2. The University of Liverpool is a member of the Russell Group of leading research-intensive institutions in the UK. It attracts collaborative and contract research commissions from a wide range of national and international organisations valued at more than £93 million annually.
You must be logged in to post a comment.
All recent news
Postcard: Citizens’ jury debate ethical use of electronic health data in Uganda
Institute of Irish Studies’ first Artist in Residence, Fion Gunn brings exhibition to VG&M
Without a fresh new vision, the next Conservative prime minister risks leading their party to election loss
Student Excellence Awards launched by The Pandemic Institute
There's still a few days left to see our own Professor Tom Solomon @RunningMadProf performing his 'Covid for Kids' show at #EdinburghFringe!
All the details + booking info for the final few tickets here ➡️ https://www.pleasance.co.uk/event/covid-kids#overview
“I expect them [dog bites] to keep increasing. Unless there is a fundamental change in our relationships to dogs or some sort of over-arching legislative change that will come in," says Dr John Tulloch @JT_EpiVet https://inews.co.uk/news/mystery-over-dog-bite-increase-as-incidents-double-in-the-past-20-years-1778116
An important new project funded by @ukhomeoffice led by @LCritical and @LivUniPsyc researchers lworking with @NCA_UK are developing online child protection tools supporting law enforcement agencies to safeguard children. Read more at @livuninews here: https://tinyurl.com/livunisafeguardchildren