Scientists at the University of Liverpool have developed a new method to detect proteins associated with longevity, which helps further our understanding into why some animals live longer than others.
The team looked at the genome of more than 30 mammalian species to identify proteins that evolve in connection with the longevity of a species. They found that a protein, important in responding to DNA damage, evolves and mutates in a non-random way in species that are longer-lived, suggesting that it is changing for a specific purpose. They found a similar pattern in proteins associated with metabolism, cholesterol and pathways involved in the recycling of proteins.
Findings show that if certain proteins are being selected by evolution to change in long-lived mammals like humans and elephants, then it is possible that these species have optimised pathways that repair molecular damage, compared to shorter-lived animals, such as mice.
The study, led by Dr Joao Pedro Magalhaes and postgraduate student, Yang Li, is the first to show evolutionary patterns in biological repair systems in long-lived animals and could, in the future, be used to help develop anti-ageing interventions by identifying proteins in long-lived species that better respond to, for example, DNA damage. Proteins associated with the degradation of damaged proteins, a process that has been connected to ageing, were also linked with the evolution of longevity in mammals.
Dr Magalhaes, from the University’s Institute of Integrative Biology, said: “The genetic basis for longevity differences between species remains a major puzzle of biology. A mouse lives less than five years and yet humans can live to over 100 for example. If we can identify the proteins that allow some species to live longer than others we could use this knowledge to improve human health and slow the ageing process.
“We developed a method to detect proteins whose molecular evolution correlates with longevity of a species. The proteins we detected changed in a particular pattern, suggesting that evolution of these proteins was not by accident, but rather by design to cope with the biological processes impacted by ageing, such as DNA damage. The results suggest that long-lived animals were able to optimise bodily repair which will help them fend off the ageing process.”
The research is published in the American Aging Association‘s journal, AGE.
How do you think that pathways to repair molecular damage might relate to the well-known relation between cephalic index and species longevity?
You must be logged in to post a comment.
All recent news
University Hardship Fund open for applications
Gene expression study sheds new light on African Salmonella
International collaboration publishes design for post-LHC future circular collider
Exam offer: Free access to the gym, pool and classes
Obituary: David Downham
'Behind the paper' - #LSTM's @RachelHClare blogs on @naturemicrobiol about her recent paper on 'Potential novel fast acting drug candidates identified to cure filarial diseases' https://t.co/1kpvkoADi9
#hotnews International collaboration publishes design for post-LHC future circular collider. Find out more 👉 https://t.co/Ff8J7GtdN0
Listen to Dr Christienna Fryar from @LivUniHistory on @BBCRadio4 Battles that Won our Freedoms discussing the Jamaican slave rebellion in 1831 that contributed to Britain's abolition of slavery https://t.co/36F7yOmvUr