Dr Paul L. Domanico: “This project partners two substantial organisations committed to transforming the treatment of disease for patients in low resource settings”
Research at the University of Liverpool could benefit millions of HIV patients in developing countries through a nano-technology programme aimed at making drug treatment more effective.
The Liverpool programme to date has focused on developing nano-sized particles of antiretroviral drugs to increase their stability and absorption. However, a significant number of HIV treatments are not compatible with current technologies.
Broaden the capabilities
To address this, the University is collaborating with the Clinton Health Access Initiative (CHAI) in an attempt to broaden the capabilities of nano-technology. They will work with a widely used HIV drug, and combine that with commonly used ingredients in an attempt to create stable nano-particles.
According to World Health Organisation (WHO) figures, 9.7 million people had access to antiretroviral therapy around the world in 2012, but there are estimated to be 35.3 million people living with HIV. With a limited health budget in developing countries, authorities face difficult challenges in making more treatment available.
Nanomedicine is an emerging field of drug development that utilises particles at the nano scale (one millionth of a millimetre). One of the benefits of these types of therapies is that they can increase the amount of drug where it is needed. In the case of this research, the goal is to prevent drug degradation in the intestine through the use of nano-particles.
Liverpool pharmacologist, Professor Andrew Owen and CHAI senior director of research and development, Dr Paul L. Domanico are leading this project. Professor Owen said: “This project is about using practical science and clinical expertise to broaden the utility of a new technology. These approaches could deliver a step-change for drug delivery in cases of HIV.”
Dr Domanico added, “This project partners two substantial organisations committed to transforming the treatment of disease for patients in low resource settings.”
Nanomedicine candidates will be generated and characterised in the University’s Department of Chemistry by Professor Steve Rannard’s team and subsequently studied in the Department of Molecular and Clinical Pharmacology under the supervision of Professor Andrew Owen and Dr Marco Siccardi. The research will also use state-of-the-art mathematical modelling techniques to bridge between disciplines.
Preclinical data published
The research builds on existing HIV work between the University’s Department of Molecular and Clinical Pharmacology and Department of Chemistry that has already received more than £6 million investment. The project will also be support by existing and on-going preclinical pharmacology studies performed by CHAI.
The Liverpool team has published preclinical data showing that that there may be benefits for dose reduction of other HIV drugs and clinical trials are planned for later in 2014. If successful these would form the first oral nanomedicines for HIV.
Find out more about about studying at University of Liverpool, please visit our Study pages.
You must be logged in to post a comment.
All recent news
SAVSNET scoops prize at Innovator of the Year awards
£460k boost for clinical trials methodology research partnership
Explore The Viking Age in the North West with new app
Top 10 tips to manage exam stress
Alumnus receives top honour from Institute of Electrical and Electronics Engineers (IEEE)
Should the UK voting age be lowered? Our VC Professor Dame Janet Beer introduces @LivUniPol Prof Jon Tonge at tonight's #LivOpenHouse event, '16 - old enough to have sex but not to vote?'
Explore Viking #Wirral with our new, free The #Viking Age in the North West app! Available for #Android and #iOS. All the details > https://t.co/mhd6yvMPit
On the 50th anniversary of the UK becoming the first state to lower the voting age to 18, tonight's #LivOpenHouse event (6pm) looks at arguments for and against further lowering to 16, as has happened in Scotland for most elections and is happening in Wales. Good or bad idea?