The study suggests Complex Regional Pain Syndrome could be caused by harmful serum-autoantibodies
Researchers at the University of Liverpool have taken a major step forward in understanding the causes of a disorder which causes chronic pain in sufferers.
Complex Regional Pain Syndrome (CRPS) is a serious condition affecting a limb after an – often small – accident or operation. It can cause severe pain lasting many years, as well as limb swelling, hair and nail growth changes, and muscle atrophy, but until now there has been no clear evidence of the cause.
Now the research team from the University’s Institute of Translational Medicine alongside colleagues at the University of Pecs, Hungary have successfully transferred antibodies from the serum of patients with CRPS to mice, causing many of the same symptoms to be replicated.
Dr Andreas Goebel, who works in the University of Liverpool and is a Consultant in Pain Medicine at The Walton Centre NHS Foundation Trust, led the study. He said: “CRPS is a serious condition which isn’t fully understood. The findings of this study hint at a cause for it – harmful serum-autoantibodies – and raise the possibility of finding a treatment.”
Although it had previously been thought, that the cause of CRPS is exclusively an abnormal brain activity after injury, more recent results, including from the Liverpool group have pointed to an immune dysfunction.
Pinpoint the cause
Dr Goebel said: “It’s quite possible that CRPS is caused by a fault in the immune system. This study seems to pinpoint the cause as autoantibodies, and by examining this area further we can look to develop a cure.”
The project was subsidised by the European Union and co-financed by the European Social Fund. 7, the Pain Relief Foundation, Liverpool, UK,
CSL-Behring AG, Bern, Switzerland, BPL Ltd, UK, Biotest AG, Dreieich, Germany.
The study was published in the journal Pain and can be read here.
You must be logged in to post a comment.
All recent news
Dr Laura Bonnett recognised at Women in Data awards
The 14 former Liverpool students contesting General Election 2019
Blog: My Top 5 ‘Christmassy’ things to do in Liverpool!
Current treatment for fungal meningitis is fuelling drug resistance
Glaciologists urge action on climate change to halt glacier melting
Tickets for our @Ri_Science #xmaslectures live-screening event are going fast so be sure to get yours while you still can! Join us on 12 Dec for a whole lot of family-friendly festive fun! 🎄 #maths #scicomm #livuniengage
It’s lonely being a Tory candidate in deep-red Liverpool... @DrDavidJeffery - who specialises in the decline of the Conservative vote in Merseyside - talks @TheEconomist 👉 https://www.economist.com/britain/2019/12/07/its-lonely-being-a-tory-candidate-in-deep-red-liverpool
#GE2019 #GeneralElection2019 #GeneralElection19 @LivUniPol
The 14 former @livuni students contesting General Election 2019 👉 https://news.liverpool.ac.uk/2019/12/06/the-14-former-liverpool-students-contesting-general-election-2019/
#GeneralElection2019 #GeneralElection19 #GE19