Sign in: Staff/Students
The study used samples taken from young and old horses, which have similar tendon properties to those of humans
University of Liverpool scientists have examined the mechanisms that cause ageing in the tendons of horses, opening up the possibility of better treatment for humans.
It has been understood for many years that tendons are highly prone to injury and that this likelihood increases as they age. Why this happens, is currently poorly understood
Now, using samples taken from young and old horses, which have similar tendon properties to those of humans, the team of researchers, which also included scientists from Queen Mary University of London, performed a range of tests to profile the types, quantities and proportions of proteins present in the tendon.
“We’re now starting to get to the ‘why’ of this process by showing that the proteins produced by the cells to repair damage alter as we get older.”
The findings of this research also showed that certain protein fragments appear in greater quantities in older horses, suggesting that they are released as the tissue is slowly damaged over time.
In contrast, damaged tendons in younger horses were found to contain more of the proteins used in healing than the damaged samples from old horses, suggesting that healing also slows with age.
Professor Clegg said: “This now opens up the possibility of better treatment and prevention strategies to address tendon injuries in both man and veterinary species such as the horse.”
The study, ‘Proteomic analysis reveals age-related changes in tendon matrix composition, with age-and injury-specific matrix fragmentation’, was published in the Journal of Biological Chemistry. It was funded by the Horserace Betting Levy Board, Wellcome Trust and the Biotechnology and Biological Sciences Research Council (BBSRC).
You must be logged in to post a comment.
All recent news
Summer Term Events Programme (STEP) – My review of week one
New book explores how to be a happier, healthier dog owner
‘Magical Music Trails’ –walking trails and photography competition still open for entries
Play your part as Yoko Ono Lennon Centre approaches final funding milestone
Result of ballot for industrial action over restructuring of the University’s Faculty of Health and Life Sciences
Our paper on immune responses to COVID vaccine (mostly Pfizer) in 237 healthcare workers, 124 #SARSCoV2 naïve and 113 previously infected, from the PITCH consortium @pitchstudy is out as a pre-print today.
See if you can spot us in the new @NetflixUK series, The Irregulars! 📽️
Our @VictoriaGallery appears in it, as well as other locations across the city including St George’s Plateau, the Palm House in Sefton Park and Falkner Street in the Georgian Quarter.
Professor Michael Parkinson CBE, author of 1985's Liverpool on the Brink, and Liverpool Beyond the Brink in 2019, analyses the Caller Report, the Gov's Best Value inspection into Liverpool City Council