Sign in: Staff/Students
Researchers from the University of Liverpool, working with colleagues from Oxford and international partners, have improved the understanding of the processes that can lead to the development of type 2 diabetes.
The research, published in Nature Genetics, shows how specific genetic variants can impact the risk a person has of developing the disease.
Identifying DNA sequence changes that are most likely involved in mediating diabetes risk, the researchers determined what was ‘special’ about those changes. They were able to find a strong signal for the positions in the genome that interact with a regulatory protein which has an important role in ensuring genes work correctly
Study involved analysis of large-scale genetic data from over 200,000 individuals (one quarter with diabetes) and focused on regions of the genome that have recently been identified as being important in relation to type 2 diabetes risk.
Wellcome Trust Senior Research Fellow Professor Andrew Morris, from the University’s Institute of Translational Medicine, said: “Previously, it has not been clear how genetic variants impact disease risk. However, by getting closer to many of the specific genetic changes that influence diabetes risk, we could for the first time detect signals that are important in the development of the disease.”
Wellcome Trust Senior Investigator Professor Mark McCarthy from Oxford University, said: “We were able to identify specific signatures of DNA variants that influence individual risk of type 2 diabetes. This is an important step forward in our ability to connect genetic findings to molecular events in key organs, and to understand the biological processes involved.”
Professor Andrew Morris added: “Our study of these genetic variants has furthered our understanding of the underlying biological processes involved in type 2 diabetes and other complex human diseases, offering a promising avenue for translation into clinical practice.”
The full paper can be found on the following site: http://bit.ly/1EUBgNj
You must be logged in to post a comment.
All recent news
Stephen Lawrence Day 2021
New research to explore experiences of walking and creativity during COVID-19
Unpreneur: A free enterprise and start-up bootcamp for students
Explore hidden world of microbes in new comic book
Engineers partner in `Smarter Testing’ project for aerospace sector
Our paper on immune responses to COVID vaccine (mostly Pfizer) in 237 healthcare workers, 124 #SARSCoV2 naïve and 113 previously infected, from the PITCH consortium @pitchstudy is out as a pre-print today.
See if you can spot us in the new @NetflixUK series, The Irregulars! 📽️
Our @VictoriaGallery appears in it, as well as other locations across the city including St George’s Plateau, the Palm House in Sefton Park and Falkner Street in the Georgian Quarter.
Professor Michael Parkinson CBE, author of 1985's Liverpool on the Brink, and Liverpool Beyond the Brink in 2019, analyses the Caller Report, the Gov's Best Value inspection into Liverpool City Council