Sign in: Staff/Students
A ‘living bandage’ made from stem cells, which could revolutionise the treatment and prognosis of a common sporting knee injury, has been trialled in humans for the first time by scientists at the Universities of Liverpool and Bristol.
Meniscal tears are suffered by over one million people a year in the US and Europe alone and are particularly common in contact sports like football and rugby. 90% or more of tears occur in the white zone of meniscus which lacks a blood supply, making them difficult to repair. Many professional sports players opt to have the torn tissue removed altogether, risking osteoarthritis in later life.
The Cell Bandage has been developed by spin-out company Azellon, and is designed to enable the meniscal tear to repair itself by encouraging cell growth in the affected tissue.
A prototype version of the Cell Bandage was trialled in five patients, aged between 18 and 45, with white-zone meniscal tears. The trial received funding support from Innovate UK and the promising results have been published today in the journal Stem Cells Translational Medicine.
The procedure involved taking stem cells, harvested from the patient’s own bone marrow, which were then grown for two weeks before being seeded onto a membrane scaffold that helps to deliver the cells into the injured site. The manufactured Cell Bandage was then surgically implanted into the middle of the tear and the cartilage was sewn up around the bandage to keep it in place.
All five patients had an intact meniscus 12 months post implantation. By 24 months, three of the five patients retained an intact meniscus and had returned to normal knee functionality whilst the other two patients required surgical removal of the damaged meniscus due to a new tear or return of symptoms.
Professor Anthony Hollander, Chair of Stem Cell Biology at the University of Liverpool and Founder and Chief Scientific Officer of Azellon, said: “The Cell Bandage trial results are very encouraging and offer a potential alternative to surgical removal that will repair the damaged tissue and restore full knee function.
“We are currently developing an enhanced version of the Cell Bandage using donor stem cells, which will reduce the cost of the procedure and remove the need for two operations.”
The Cell Bandage was produced by the Advanced Therapies Unit at the NHS Blood & Transplant facility in Speke, Liverpool and implanted into patients at Southmead Hospital in Bristol, under the supervision of Professor Ashley Blom, Head of Orthopaedic Surgery at the University of Bristol.
Professor Blom commented: “The Cell Bandage offers an exciting potential new treatment option for surgeons that could particularly benefit younger patients and athletes by reducing the likelihood of early onset osteoarthritis after meniscectomy.”
A spokesperson for Innovate UK said: “Turning stem cell research into clinical and commercial reality requires close collaboration between businesses, universities, and Hospitals. It’s great to see this inter-disciplinary approach has led to such an exciting outcome from this first-in-human trial.”
The paper ‘Repair of torn avascular meniscal cartilage using undifferentiated autologous mesenchymal stem cells: from in vitro optimisation to a first-in-human study is published in Stem Cells Translational Medicine. [DOI: 10.1002/sctm.16-0199]
You must be logged in to post a comment.
All recent news
Winter break: How to travel safety
Liverpool academics named in global list of influential researchers
Liverpool invests in immunology cancer research
Insider Imprint student journal launches new podcast series
Event today: Brexit Information for EU Students
WE’RE LIVE! 💰
Join @KieranMaguire and @introspective81 for a tell-all talk on finance in the modern game.
If you’re after no-nonsense takes on Project Big Picture, European breakaways and club ownership, this one’s definitely for you.
STREAMING NOW: https://youtu.be/DwAf9e2_bew
World-leading experimental cancer researcher Professor Christian Ottensmeier has joined Liverpool to lead a major new programme of cutting-edge #immunology #cancer research in collaboration with local #NHS partners.
Full story ➡️ https://bit.ly/2V1tpga
We are delighted to invite you to join us on Friday for '@GeorgeHarrison: Transcending the Beatles' with @bbcmerseyside legend Roger Philips, @LivUni lecturer Dr Mike Jones & award-winning film producer & widow of George #OliviaHarrison.
27 Nov | 1pm GMT: https://bit.ly/2KExIw5