Researchers from the University’s Institute of Translational Medicine have determined the most effective drug dose to help penguins in managed care fight off disease.
Aspergillosis is a common respiratory fungal disease in African penguins (Spheniscus demersus) under managed care. Historically this disease was treated with the antifungal medication itraconazole.
Unfortunately, due to drug resistance, this treatment failed. Recently another antifungal medication, voriconazole, has been used but, due to the dosing being based on other avian medications, this has resulted in the penguins suffering from adverse drug effects.
Researchers, led by Dr Katharine Stott, sought to determine the safest and most effective dose of voriconazole for African penguins.
They evaluated the effectiveness of multiple single and daily oral doses of voriconazole by analysing the concentration of the drug in plasma taken from the penguins during two trials.
The researchers used the data to construct a mathematical model to describe how the penguins metabolise voriconazole and to predict drug exposure. Using the model, they were then able to simulate alternative dosing strategies to find one that replicated the drug exposure known to be effective in humans, whilst avoiding toxicity.
The research, published in BioOne, demonstrated that administration of 5mg/kg voriconazole once daily is a safe and effective dosing strategy for African Penguins with invasive aspergillosis.
Dr Stott, said: Although this project was a somewhat unusual one for our group, the problem it presents is common: how can we better understand dosing strategies to optimise the use of antimicrobial agents?
“The project also dealt with an issue commonly faced when trying to design paediatric treatment regimens in that dosing requirements are not always proportionally related to patient size.”
The full paper, entitled ‘Pharmacokinetics of orally administered voriconazole in African penguins after single and multiple doses’, can be found here here.
You must be logged in to post a comment.
All recent news
PGR training opportunity: ‘Thriving through Change’ three-part webinar series
Helibron Leadership Programme 2020 – First cohort underway
University launches new Crisis Support Fund for students affected by COVID-19
COVID-19: We are not “all in it together”
New hardship fund available for students affected by COVID-19
Liverpool’s response to COVID19: Join us on Friday 29 May 1200-1300 for the STOP COVID Webinar.
For more information visit: https://bit.ly/2TEYAxt
To register visit: https://bit.ly/3c2zTBB
#STOPCOVID #LHPCOVID #COVID19
Front page of our News site this morning 🗞️
Crisis support fund for students as part of our #LivUniCOVID Emergency Response Campaign, & opinion from 3 of our #publichealth experts on #Covid_19 health inequalities.
Find it all here ➡️http://news.liverpool.ac.uk
In our NEW blog @MeredithCrowle1 and Dr Lu Han look at whether 'level playing fields' will derail the Brexit negotiations.
READ it here 🔻
@stjohnscam @Cambridge_Uni @UoLManSchool @LivUni @livuninews