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The University is part of an international team of scientists that have identified the climatic risks for dengue disease outbreaks with a new study undertaken in India.
This was achieved by evaluating the relationship of climatic factors in the spread of dengue in different climatic zones in the country through the states of Punjab, Haryana, Rajasthan, Gujarat and Kerala. The researchers focused on changes in a factor called ‘extrinsic incubation period (EIP)’ of the dengue virus by taking into account daily and monthly mean temperatures in these areas.
EIP is the time taken for incubation of the virus in the mosquito. During this period, after the mosquito draws a virus-rich-blood meal, the virus escapes the gut, passes through the mosquito’s body and reaches it salivary glands. Once this happens, the mosquito is infectious and capable of transmitting the virus to a human host.
It has been found that climatic conditions play an important role in EIP. Lower temperatures (17–18 °C) result in longer EIPs thereby leading to decreased virus transmission. With increasing temperatures, feeding increases because of enhanced metabolism of the mosquito, leading to shorter EIPs.
Even a 5-day decrease in the incubation period can hike transmission rate by three times, and with an increase in temperature from 17 to 30 °C, dengue transmission increases fourfold. However, a further increase in temperature beyond 35 °C is detrimental to the mosquito survival.
The study was conducted by the University of Liverpool in collaboration with the Hyderabad-based Indian Institute of Chemical Technology (IICT), National Institute of Pharmaceutical Education and Research (NIPER), Guwahati.
The researchers observed that except for Gujarat which comprises of arid regions, there was a strong correlation between rainfall and dengue disease burden. They propose an increase in breeding grounds for mosquitoes as a major reason for this finding.
The study found that Kerala being warm (temperature range 23.5-30 °C) and wet and with short EIPs (9-14 days) experiences the highest number of dengue cases. It has been found that EIP is the shortest during the monsoon season in most states and therefore there is an enhanced risk of dengue during this time.
Researchers say it is important to take into account the dynamic EIP estimates in different regions in assessing disease burden.
Dr Srinivasa Rao Mutheneni of IICT, who led the study and worked on this study during his visit to Liverpool as a University of Liverpool Indian Research Fellow, said: “This climate-based dengue forecasting model could help health authorities to assess the disease intensity in a geographic region, based on that they can plan disease control operations well in advance and optimize the use of resources meticulously.”
Changes in temperature affecting the extrinsic incubation period of the virus, future changes in the climate might have a substantial effect on dengue and other vector-borne disease burden in India.
Dr Rao added: “Though such methods are in vogue for disease control operations, we are still in the initial stages of implementation of such strategic control methods. Factors such as population density and migration also need to be included for future risk assessment studies.”
The research team included Professor Andrew P Morse and Dr Cyril Caminade, at the University of Liverpool and Srinivasa Rao Mutheneni and Suryanaryana Murty Upadhyayula, at the Indian Institute of Chemical Technology.
The study was published in the journal Emerging Microbes & Infections.
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